EC Number   |
Natural Substrates |
|---|
    2.4.1.135 | more |
the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans |
| 2.4.1.135 | more |
mutant lacking glucuronosyltransferase I fails to make both heparan sulfate and chondroitin sulfate |
| 2.4.1.135 | more |
the enzyme forms the glycosaminoglycan-protein linkage region, GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser, of the proteoglycans |
| 2.4.1.135 | more |
enzyme is involved in heparan sulfate and chondroitin sulfate biosynthesis |
| 2.4.1.135 | more |
central enzyme in the initial steps of proteoglycan synthesis |
| 2.4.1.135 | more |
expressed in Pichia pastoris |
| 2.4.1.135 | more |
enzyme plays a key role in proteoglycan biosynthesis by catalyzing the transfer of glucuronic acid onto the trisaccharide-protein linkage structure Galbeta(1-3)Galbeta(1-4)Xyl-O-Ser, a prerequisite step for polymerization of glycosaminoglycan chains |
| 2.4.1.135 | more |
the enzyme is responsible for the complementation of the glycosaminoglycan primer sequence |
| 2.4.1.135 | UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine |
- |
| 2.4.1.135 | UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein |
plays a key role in glycosaminoglycan biosynthesis |
