EC Number   |
Natural Substrates |
|---|
    2.3.3.8 | ADP + phosphate + acetyl-CoA + oxaloacetate |
- |
| 2.3.3.8 | ATP + citrate + CoA |
- |
| 2.3.3.8 | ATP + citrate + CoA |
acetyl-CoA is produced in mitochondria, but it cannot cross the mitochondrial membranes to the cytosol. Instead, citrate is exported from mitochondria. In the cytosol, ATP-citrate lyase (ACLY; EC 2.3.3.8) catalyses the reaction to produce acetyl-CoA and oxaloacetate from citrate and ATP |
| 2.3.3.8 | ATP + citrate + CoA |
acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (ACL) is utilized to acetylate histone H3 at MyoD regulatory regions, resulting in increased MyoD expression and improved muscle regeneration after injury |
| 2.3.3.8 | ATP + citrate + CoA |
ATP citrate lyase is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis |
| 2.3.3.8 | ATP + citrate + CoA |
enzyme generates cytosolic acetyl-CoA |
| 2.3.3.8 | more |
enzyme is a nonredundant source of cytosolic acetyl-CoA |
| 2.3.3.8 | ATP + citrate + CoA |
enzyme is induced by starvation-refeeding regimen |
| 2.3.3.8 | ATP + citrate + CoA |
enzyme regulates both the direction and carbon flux of the carbon dioxide-fixing reductive tricarboxylic acid cycle |
| 2.3.3.8 | ATP + citrate + CoA |
essential enzyme for generating acetyl-CoA, a key metabolite for the first step in fatty acid synthesis and for histone acetylation. Regulation of the enzyme activity is a potentially important point of control for cell cycle regulation in the myeloid lineage |
