EC Number   |
Natural Substrates |
|---|
   2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
specific function of the enzyme in the Ca2+-dependent breakdown of calmodulin in vertebrate (eukaryotic) cells |
| 2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
Ca2+-dependent ubiquitination only of free calmodulin may provide an efficient scavenging mechanism (with subsequent breakdown) for all free calmodulin in excess of that amount which can be found by the calmodulin-binding proteins in the cell |
| 2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold |
| 2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
it is very probably that the ubiquitination of calmodulin belongs to the normal regulatory repertoire of the eukaryotic cell |
| 2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
monoubiquitylation strongly decreases the biological activity of calmodulin towards phosphorylase kinase by reducing its affinity approximately threefold and the maximal degree of activation approximately twofold |
| 2.3.2.B11 | [RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine |
specific for Ca2+-calmodulin from vertebrates, at least 3 ubiquitin molecules can be coupled to lysine residues in calmodulin |
| 2.3.2.B11 | [RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine |
Saccharomyces cerevisiae enzyme conjugates ubiquitin to yeast and bovine calmodulin |
