EC Number |
Natural Substrates |
---|
2.1.2.1 | (6S)-tetrahydrofolate + D-serine |
- |
2.1.2.1 | (6S)-tetrahydrofolate + L-serine |
- |
2.1.2.1 | 5,10-methylenetetrahydrofolate + glycine + H2O |
the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake |
2.1.2.1 | 5,10-methylenetetrahydrofolate + glycine + H2O |
- |
2.1.2.1 | L-Ser + tetrahydrofolate |
placental conversion of serine to glycine is a major source of fetal glycine |
2.1.2.1 | L-serine + tetrahydrofolate |
- |
2.1.2.1 | L-serine + tetrahydrofolate |
regulatory protein |
2.1.2.1 | L-serine + tetrahydrofolate |
major pathway for production of C1-units of 5,10-methylenetetrahydrofolate |
2.1.2.1 | L-serine + tetrahydrofolate |
enzyme is a component of thymidylate cycle |
2.1.2.1 | L-serine + tetrahydrofolate |
may play important role in central nervous system |