EC Number   |
Natural Substrates |
|---|
    2.1.1.45 | 5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP |
thymidylate synthase is the third enzyme in the methylene tetrahydrofolate cycle besides dihydrofolate reductase and serine hydroxymethyltransferase, in many organisms, thymidylate synthase is the only de novo source for dTMP required for DNA synthesis |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + deoxyuridine monophosphate |
- |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
- |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
key function in DNA synthesis, repair and cell division |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
during TS inhibition, TMP levels decrease with a subsequent increase in dUTP |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
inhibition of thymidylate synthase or of DHFR leads to thymineless death of eukaryotic organisms |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
it is a key enzyme for the synthesis of the DNA-specific nucleotide thymidylate |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
thymidylate synthase catalyses the only de novo pathway to produce thymidylate for DNA replication and repair |
| 2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP |
thymidylate synthase is a key enzyme in the de novo synthesis of dTMP |
