EC Number   |
Natural Substrates |
|---|
    2.1.1.37 | DNA + S-adenosyl-L-methionine |
- |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
DNA cytosine methylation is one of the major epigenetic gene silencing marks in the human genome facilitated by DNA methyltransferases |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
DNA GC content, CpG frequency and methylation status, overview |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
DNMT1 is crucial for cell survival |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
DNMT1 participates in epigenetic reprogramming through its ability to distinguish different categories of methylated sequences. Genomic imprinting is a mammalian epigenetic process that distinguishes maternal and paternal alleles to ensure parent-specific, monoallelic expression of imprinted genes. Preimplantation DNMT1-dependent maintenance mechanism specifically targets DMD sequences, e.g. of IAP, alpha-actin, Snurf/Snrpn, H19, Gnas, and Gtl2 DMD, overview |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
M.SssI is the only known prokaryotic C5-MTase, which recognizes the short sequence CG and thus has the same specificity as mammalian MTases |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
SinI DNA methyltransferase, a component of the SinI restriction-modification system, recognizes the sequence GG(A/T)CC and methylates the inner cytosine to produce 5-methylcytosine |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements |
| 2.1.1.37 | DNA + S-adenosyl-L-methionine |
the Z2389 DNAcytosine methyltransferase confers full protection to NotI sites by methylation of the first cytosine residue |
