EC Number   |
Natural Substrates |
|---|
   2.1.1.321 | S-adenosyl-L-methionine + [beta-catenin]-L-arginine |
the enzyme (PRMT7) upregulates the expression of C-MYC via methylating beta-catenin and inhibiting the ubiquitin-mediated degradation of beta-catenin |
| 2.1.1.321 | S-adenosyl-L-methionine + [eukaryotic translation initiation factor 2alpha]-L-arginine |
PRMT7 methylates eukaryotic translation initiation factor 2alpha (eIF2alpha) and regulates its role in stress granule formation |
| 2.1.1.321 | S-adenosyl-L-methionine + [histone H4R17]-L-arginine |
crosstalk between PRMT7 and PRMT5, where methylation of a histone H4 peptide at R17, a PRMT7 substrate, may activate PRMT5 for methylation of R3 |
| 2.1.1.321 | S-adenosyl-L-methionine + [histone H4R17]-L-arginine |
PRMT7-mediated monomethylation of histone H4 Arg17 regulates PRMT5 activity at Arg3 in the same protein |
| 2.1.1.321 | S-adenosyl-L-methionine + [histone H4R3]-L-arginine |
- |
| 2.1.1.321 | S-adenosyl-L-methionine + [protein]-L-arginine |
PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2 |
