EC Number   |
Natural Substrates |
|---|
  2.1.1.247 | a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M |
- |
| 2.1.1.247 | a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M |
- |
| 2.1.1.247 | a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M |
- |
| 2.1.1.247 | a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M |
- |
| 2.1.1.247 | HSCoM + methylcobalamin |
- |
| 2.1.1.247 | more |
corrinoid proteins mediating CoM methylation from dimethylamine or monomethylamine have a specific requirement for MT2-A, reconstitution of trimethylamine-dependent coenzyme M methylation, overview. Trimethylamine methyl transfer can interact with either isozyme of MT2 but has the greatest affinity for the A isozyme. The predominant isozyme of MT2 from in TMA-grown cells is the favored participant in the TMA:CoM methyl transfer reaction |
| 2.1.1.247 | more |
methylamine-dependent methylation of CoM mediated by trimethyamine- or monomethylamine-specific methyltransferases derived from cells grown on trimethylamine. Methylation of CoM by trimethylamine and methylation by monomethylamine are mediated by separate enzyme systems with at least one different component |
| 2.1.1.247 | [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M |
heterolytic cleavage of the methylcobamide carbon-cobalt bond with cob(I)alamin as the major product of the reaction |
