EC Number   |
Natural Substrates |
|---|
   2.1.1.244 | 3 S-adenosyl-L-methionine + eukaryotic elongation factor 1A |
enzyme N6AMT2 trimethylates eEF1A at the N-terminal site and at the adjacent lysine 79, protein substrate from Homo sapiens or Saccharomyces cerevisiae |
| 2.1.1.244 | 3 S-adenosyl-L-methionine + GPKRIA |
trimethylation by NTMT1 |
| 2.1.1.244 | 3 S-adenosyl-L-methionine + N-terminal-OLA1 |
i.e. Obg-like ATPase 1 (OLA1) protein, target validation using normal and NTMT1 knockout HEK-293FT cells demonstrates that OLA1, a protein involved in many critical cellular functions, is methylated in vivo by NTMT1 |
| 2.1.1.244 | 3 S-adenosyl-L-methionine + N-terminal-PPKRIA-[RCC1] |
- |
| 2.1.1.244 | 3 S-adenosyl-L-methionine + N-terminal-[eEF1A] |
- |
| 2.1.1.244 | 3 S-adenosyl-L-methionine + N-terminal-[RCC1] |
- |
| 2.1.1.244 | L-lysyl-[protein] + 3 S-adenosyl-L-methionine |
- |
| 2.1.1.244 | more |
the N-terminal protein methyltransferase catalyzes the modification of two ribosomal protein substrates, Rpl12ab and Rps25a/Rps25b. The yeast RPS25A and RPS25B genes and differ only at a single amino acid residue |
| 2.1.1.244 | more |
the protein N-terminal methyltransferase 1 (NTMT1) methylates the alpha-N-terminal amines of proteins |
| 2.1.1.244 | more |
alpha-N-terminal methylation of histone H2B protein in Drosophila melanogaster |
