EC Number |
Natural Substrates |
---|
2.1.1.203 | more |
NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis |
2.1.1.203 | more |
the Nsun2 fabricate 5-methylcytosine (m5C) in RNA molecules utilizing a dual-cysteine catalytic mechanism |
2.1.1.203 | more |
levels of m5C changes site-specifically and dynamically in response to oxidative stress. All individual m5C sites showing significantly different methylation levels in NSUN2-rescued cells after 2 or 4 hours of stress. Methylation levels within the same tRNA molecule are independent from each other |
2.1.1.203 | S-adenosyl-L-methionine + cytidine34 in mitochondrial tRNA |
- |
2.1.1.203 | S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor |
- |
2.1.1.203 | S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet(AUA) precursor |
- |
2.1.1.203 | S-adenosyl-L-methionine + cytosine34 in tRNA |
specific modification of cytosine34 in the intron-containing yeast pre-tRNALeu(CAA) |
2.1.1.203 | S-adenosyl-L-methionine + cytosine34 in tRNA precursor |
- |
2.1.1.203 | S-adenosyl-L-methionine + cytosine34 in tRNALeu(CAG) precursor |
- |
2.1.1.203 | S-adenosyl-L-methionine + microRNA 125b |
the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo |