EC Number   |
Natural Substrates |
|---|
   2.1.1.179 | more |
RmtC in the presence of aminoglycosides impedes methylation at the N5 position of nucleotide C1407 when the N7 position of G1405 is methylated, MALDI mass spectrometry product analysis, mechanism, overview |
| 2.1.1.179 | S-adenosyl-L-methionine + cytosine1405 in 16S rRNA |
- |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
- |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme confers resistance to aminoglycosides like gentamicin and sisomicin by specifically methylating G1405 in bacterial 16S rRNA |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme gives resistance to kanamycin plus gentamicin by converting residue C-1405 to 7-methylguanosine |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
methylation at guanine1405 mediates cellular resistance by blocking aminoglycoside binding by ribosomes |
| 2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
post-transcriptional methylation of N7-G1405 in 16S rRNA of 30S ribosomal subunits |
