EC Number |
Natural Substrates |
---|
1.8.1.12 | more |
enzyme is associated with infective capacity of the parasite |
1.8.1.12 | more |
enzyme is required for maintaining the reducing intracellular environment |
1.8.1.12 | more |
enzyme is required for maintaining the reducing intracellular redox equilibrium, trypanosomes lacking the enzyme are avirulent and show increased sensitivity to oxidative stress |
1.8.1.12 | more |
phylogenetic relationship |
1.8.1.12 | trypanothione disulfide + NADPH |
- |
1.8.1.12 | trypanothione disulfide + NADPH |
highly specific for |
1.8.1.12 | trypanothione disulfide + NADPH |
protection against oxidative stress |
1.8.1.12 | trypanothione disulfide + NADPH |
physiological function is to protect the organism from oxidative stress and to assist in maintaining low intracellular levels of hydrogen peroxide |
1.8.1.12 | trypanothione disulfide + NADPH |
scheme for trypanothione-dependent H2O2 metabolism |
1.8.1.12 | trypanothione disulfide + NADPH |
metabolizes H2O2, recombinant and wild-type cells |