EC Number   |
Natural Substrates |
|---|
   1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
- |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
natural substrate |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
recycling of excess 10-formyltetrahydrofolate that is not needed for purine biosynthesis and restoration of the tetrahydrofolate pool, important for formate metabolism by clearing it as CO2 and thus protecting cells from formate intoxication |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
regulatory mechanism to control the in vivo folate pool size |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
disposal of excess one-carbon units, oxidation of one-carbon moieties is regulated by the ratio of formyltetrahydrofolate to tetrahydrofolate in liver, regulation of the proportion of folate present in the tetrahydrofolate form, presumably to make it available for other reactions of one-carbon metabolism |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
regulation of the ratio of 10-formyltetrahydrofolate to tetrahydrofolate in the cell in response to yet unknown aldehyde and thiol metabolites |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
a major liver enzyme, contributing to more than one metabolic pathway, regeneration of the tetrahydrofolate pool, not essential for viability |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
folate-dependent metabolism of formate to carbon dioxide |
| 1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O |
regulation of the ratio of 10-formyltetrahydrofolate to tetrahydrofolate and of the purine biosynthesis through control of the level of 10-formyltetrahydrofolate, down-regulation of FDH in tumors is one of the cellular mechanisms that enhance proliferation, FDH possesses tumor specific suppressor effects |
