EC Number   |
Natural Substrates |
|---|
  1.5.1.18 | (-)-ephedrine + NAD+ |
first step in the catabolism of (-)-ephedrine |
| 1.5.1.18 | (-)-ephedrine + NAD+ |
plays role in the metabolism of quite a number of different aromatic and aliphatic amino alcohols |
| 1.5.1.18 | (-)-ephedrine + NAD+ |
- |
| 1.5.1.18 | (R,R)-(-)-pseudoephedrine + NAD+ |
- |
| 1.5.1.18 | (R,S)-(-)-ephedrine + NAD+ |
- |
| 1.5.1.18 | 1-phenylpropan-1,2-dione + NAD+ |
- |
| 1.5.1.18 | 1-phenylpropan-1,2-dione + NAD+ |
EDH overcomes the stability of the conjugated molecule PPD by reducing it to alpha-hydroxyketone (R)- and (S)-PAC, respectively. Phenylacetylcarbinol (PAC) cannot be oxidized by these dehydrogenases and possibly undergoes a cleavage reaction to yield benzaldehyde and acetaldehyde |
| 1.5.1.18 | more |
ephedrine dehydrogenase (EDH) exhibits strict selectivity for the oxidation of the diastereomers (R,S)-(-)-ephedrine and (R,R)-(-)-pseudoephedrine. Conversion of all ephedrine isomers required the addition of NAD+ as an oxidant. Without a surplus oxidant or in the presence of NADP+, cell lysates do not significantly convert ephedrine |
