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EC Number	Natural Substrates	Commentary (Nat. Sub.)
1.3.1.B13	a polyprenol + NADPH + H+	-
1.3.1.B13	a polyprenol + NADPH + H+	the enzyme (SRD5A3) is necessary for the reduction of the alpha-isoprene unit of polyprenols to form alpha-reduced dolichols, required for synthesis of dolichol-linked monosaccharides, and the oligosaccharide precursor used for N-glycosylation. The presence of residual dolichol in cells depleted for this enzyme suggests the existence of an unexpected alternative pathway for dolichol de novo biosynthesis

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Release 2023.1 (January 2023)