EC Number   |
Natural Substrates |
|---|
   1.3.1.20 | 5alpha-dihydrotestosterone + NADPH + H+ |
- |
| 1.3.1.20 | camphorquinone + NADPH + H+ |
enzyme has dehydrogenase and reductase activities, enzyme is identical to NADP+-dependent D-xylose dehydrogenase |
| 1.3.1.20 | more |
reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series |
| 1.3.1.20 | more |
metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons |
| 1.3.1.20 | more |
involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs |
| 1.3.1.20 | more |
metabolic inactivation of exogeneous xenobiotics |
| 1.3.1.20 | more |
detoxification of polycyclic aromatic trans-hydrodiols by formation of o-quinones from the reaction product of dihydrodiol oxidation |
| 1.3.1.20 | more |
enzyme catalyzes formation of benz[a]anthracene-1,2-dihydrodiol which causes Cu[II]-mediated DNA damage including 8-oxo-7,8-dihydro-2-deoxyguanosine formation in the presence of NAD+ |
| 1.3.1.20 | more |
enzyme-mediated oxidative damage is involved in the hydroxychavicol and benzo[a]pyrene-induced toxic effects |
| 1.3.1.20 | more |
dihydrodiol dehydrogenase catalyzes the NADP+-linked oxidation of dihydrodiols of aromatic hydrocarbons to their corresponding catechols and is regarded as a toxication enzyme in the metabolism of carcinogenic polycyclic aromatic hydrocarbons because oxidation by the enzyme yields reactive and redox-active ortho-quinones and reactive oxygen species, broad substrate specificity indicates additional roles of the enzyme in the metabolism of endogenous and xenobiotic carbonyl compounds and the prevention of the development of glycation |
