EC Number   |
Natural Substrates |
|---|
   1.3.1.124 | (2E,4E)-2,4-decadienoyl-CoA + NADPH + H+ |
- |
| 1.3.1.124 | (2E,4E)-2,4-octadienoyl-CoA + NADPH + H+ |
- |
| 1.3.1.124 | (2E,4Z)-2,4-decadienoyl-CoA + NADPH + H+ |
preferred over substrate (2E,4E)-2,4-decadienoyl-CoA |
| 1.3.1.124 | 2-cis,4-cis/trans-dienoyl-CoA + NADPH + H+ |
- |
| 1.3.1.124 | 2-trans,4-cis-decadienoylcarnitine + ? |
abnormal unsaturated fatty acid oxidation |
| 1.3.1.124 | more |
enzyme is the key enzyme of beta-oxidation of unsaturated fatty acid in mitochondria and to a lesser extent in peroxisomes, three accessory proteins are involved in the pathway |
| 1.3.1.124 | more |
key enzyme in the beta-oxidation of unsaturated fatty acids, naturally occuring lethal enzyme deficiency |
| 1.3.1.124 | more |
2,4-dienoyl-CoA reductase as an auxiliary enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids |
| 1.3.1.124 | more |
DECR may also play a role in the degradation of fatty acids containing odd-numbered double bonds because the intermediate 2,5-dienoyl-CoA may be isomerized by enoyl-CoA isomerase to 3,5-dienoyl-CoA and then converted to 2,4-dienoyl-CoA by a specific delta3,5,delta2,4-dienoyl-CoA isomerase |
| 1.3.1.124 | more |
in eukaryotes, double bonds in even-numbered positions are reduced by an NADPH-dependent 2,4-dienoyl-CoA reductase to 3-enoyl-CoA, which is then isomerized by enoyl-CoA isomerase to trans-2-enoyl-CoA, suitable for further oxidation |
