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EC Number
Natural Substrates
Commentary (Nat. Sub.)
1.2.1.84
a long-chain acyl-CoA + 2 NADPH + 2 H+
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1.2.1.84
docosanoyl-CoA + 2 NADPH + 2 H+
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1.2.1.84
eicosanoyl-CoA + 2 NADPH + 2 H+
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1.2.1.84
hexacosanoyl-CoA + 2 NADPH + 2 H+
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1.2.1.84
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Waterproof is a Drosophila FAR with a preference for very long chain, saturated fatty acids of 24 and 26 carbons. In yeast cultures expressing Waterproof, tetracosanoyl-alcohol (24:0-OH) and hexacosanoyl-alcohol (26:0-OH) are identified by GC/MS analysis, unsaturated alcohols or alcohols of shorter chain-lengths are either absent or below the detection limit. Neither of these fatty alcohols is detected in the vector control yeast culture or the wat gene containing culture grown under non-inducing conditions
1.2.1.84
tetracosanoyl-CoA + 2 NADPH + 2 H+
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