EC Number   |
Natural Substrates |
|---|
    1.2.1.3 | 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O |
- |
| 1.2.1.3 | 3-hydroxypropionaldehyde + NAD+ + H2O |
- |
| 1.2.1.3 | 4-hydroxy-2-nonenal + NAD+ + H2O |
- |
| 1.2.1.3 | 4-hydroxy-2-nonenal + NAD+ + H2O |
poor substrate of isoform ALDH3A1 |
| 1.2.1.3 | acetaldehyde + NAD+ + H2O |
- |
| 1.2.1.3 | acetaldehyde + NAD+ + H2O |
mutations in Aldh2 strongly segregate with the phenotypes of low and high alcohol consumption and with kinetic differences in ALDH2, suggesting that pharmacogenetic differences affect voluntary alcohol consumption. Bases mutated in the coding region suggest that aldh2(2) in low drinkers is ancestral to the coding changes of either aldh2(1) or aldh2(3), which segregate with higher ethanol consumption |
| 1.2.1.3 | acetaldehyde + NAD+ + H2O |
rats with an mutated allele for aldehyde dehydrogenase (ALDH2-2) show a low alcohol consumption phenotype. Homozygous ALDH2-2 rats derived from high-drinker F0 females showed a remarkly higher ethanol consumption than homozygous animals derived from low-drinker females. Mitochondria of F2 rats derived from high alcohol-consuming females were more active in oxidizing substrates that generate NADH for complex I |
| 1.2.1.3 | all-trans-retinal + NAD+ + H2O |
- |
| 1.2.1.3 | alpha-aminoadipate semialdehyde + NAD+ + H2O |
- |
| 1.2.1.3 | an aldehyde + NAD+ + H2O |
- |
