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Results 1 - 4 of 4

EC Number	Natural Substrates	Commentary (Nat. Sub.)
1.2.1.25	3-methyl-2-oxobutanoate + CoA + NAD+	-
1.2.1.25	3-methyl-2-oxopentanoate + CoA + NAD+	-
1.2.1.25	4-methyl-2-oxopentanoate + CoA + NAD+	-
1.2.1.25	more	the human BCKD complex catalyzes the irreversible oxidative decarboxylation of the branched-chain ketoacids (2-keto-isocaproate derived from leucine, 2-keto-3-methylglutarate obtained from isoleucine, and 2-keto-isovalerate from valine). This reaction produces CO2, NADH, and the respective branched-chain acyl-coA intermediates with a 1:1:1 stoichiometry. The action of BCKD complex generates isovaleryl-CoA from 2-ketoisocaproate (leucine), 2-methylbutyryl-CoA from 2-keto-3-methylglutarate (isoleucine), and isobutyryl-CoA from 2-keto-isovalerate (valine)

Results 1 - 4 of 4

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Release 2023.1 (January 2023)