EC Number   |
Natural Substrates |
|---|
   1.14.99.29 | eIF5A-N6-(4-aminobutyl)-L-lysine + AH2 + O2 |
- |
| 1.14.99.29 | eIF5A-N6-(4-aminobutyl)-L-lysine + AH2 + O2 |
activation of eIF5A |
| 1.14.99.29 | eIF5A-N6-(4-aminobutyl)-L-lysine + AH2 + O2 |
different eIF5A isozymes exist, no activity with eIF5A mutant K51R, that lacks hypusine. The unique posttranslational modification occurs in only one cellular protein, the eukaryotic translation initiation factor 5A, eIF5A |
| 1.14.99.29 | eIF5A-N6-(4-aminobutyl)-L-lysine + AH2 + O2 |
different eIF5A isozymes exist. The unique posttranslational modification occurs in only one cellular protein, the eukaryotic translation initiation factor 5A, eIF5A |
| 1.14.99.29 | eIF5A-N6-(4-aminobutyl)-L-lysine + AH2 + O2 |
the DOHH reaction is irreversible |
| 1.14.99.29 | eIF5A-N6-(4-aminobutyl)-L-lysine + AH2 + O2 |
the unique posttranslational modification occurs in only one cellular protein, the eukaryotic translation initiation factor 5A, eIF5A |
| 1.14.99.29 | eIF5A-Nepsilon-(4-aminobutyl)lysine + AH2 + O2 |
the enzyme catalyzes the final step of the post-translational synthesis of hypusine, i.e. Nepsilon-(4-amino-2-hydroxybutyl)lysine, in the eukaryotic translation initiation factor 5A, eIF5A |
| 1.14.99.29 | eIF5A-Nepsilon-(4-aminobutyl)lysine + AH2 + O2 |
the enzyme catalyzes the maturation of eukaryotic initiation factor 5A, synthesis of hypusine is essential for the function of eIF5A in eukaryotic cell proliferation and survival |
| 1.14.99.29 | eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 |
- |
| 1.14.99.29 | more |
eIF5A occurs in tumor cells, and it also acts as a cofactor of the Rev transactivator protein in HIV-1-infected cells |
