EC Number |
Natural Substrates |
---|
1.14.15.6 | (20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 |
- |
1.14.15.6 | (22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 |
- |
1.14.15.6 | cholesterol + 2 reduced adrenodoxin + O2 |
- |
1.14.15.6 | cholesterol + 6 reduced adrenodoxin + 3 O2 |
- |
1.14.15.6 | cholesterol + 6 reduced adrenodoxin + 3 O2 |
first step in biosynthesis of all steroid hormones |
1.14.15.6 | cholesterol + 6 reduced adrenodoxin + 3 O2 |
overall reaction |
1.14.15.6 | cholesterol + reduced adrenal ferredoxin + O2 |
- |
1.14.15.6 | cholesterol + reduced adrenal ferredoxin + O2 |
first and rate-limiting enzyme in adrenal steroidogenesis |
1.14.15.6 | cholesterol + reduced ferredoxin + O2 |
metabolic regulation of enzyme expression, overview |
1.14.15.6 | cholesterol + reduced ferredoxin + O2 |
the catalyzed reaction is not the rate-limiting step in steroidogenesis except in placenta which lacks the steroidogenic acute regulatory protein, overview, enzyme deficiency by mutations leads to severe disorders, overview |