EC Number   |
Natural Substrates |
|---|
    1.14.14.19 | 2 progesterone + 2 AH2 + 2 O2 |
- |
| 1.14.14.19 | 7-dehydropregnenolone + [reduced NADPH-hemoprotein reductase] + O2 |
- |
| 1.14.14.19 | a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 |
- |
| 1.14.14.19 | more |
it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol |
| 1.14.14.19 | more |
catalyzes the last step of androgen biosynthesis in both testes and adrenals |
| 1.14.14.19 | more |
CYP17 is a key enzyme in steroid hormone biosynthesis |
| 1.14.14.19 | more |
the enzyme catalyzes the key branch point in the metabolic conversion of cholesterol either to androgens and estrogens, or to glucocorticoids |
| 1.14.14.19 | more |
the enzyme is is essential for the maintenance of normal male and female sexual characteristics, as well as the stress response and mineral balance in all mammals |
| 1.14.14.19 | more |
the enzyme is required for androgen production, genetic regulation, overview |
| 1.14.14.19 | more |
CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin |
