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Results 1 - 6 of 6

EC Number	Natural Substrates	Commentary (Nat. Sub.)
1.14.13.231	chlortetracycline + NADPH + H+ + O2	-
1.14.13.231	demeclocycline + NADPH + H+ + O2	-
1.14.13.231	doxycycline + NADPH + H+ + O2	-
1.14.13.231	minocycline + NADPH + H+ + O2	-
1.14.13.231	more	the enzyme shows a broad tetracycline antibiotic spectrum and a requirement for molecular oxygen and NADPH in antibiotic degradation. The tetracycline products are unstable at neutral pH, but mass spectral and NMR characterization under acidic conditions support initial monohydroxylation at position 11a followed by intramolecular cyclization and non-enzymatic breakdown to other undefined products
1.14.13.231	tetracycline + NADPH + H+ + O2	-

Results 1 - 6 of 6

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Release 2023.1 (January 2023)