EC Number   |
Natural Substrates |
|---|
    1.13.11.33 | 2 arachidonate + 2 O2 + H+ |
- |
| 1.13.11.33 | arachidonate + O2 |
- |
| 1.13.11.33 | arachidonate + O2 |
the enzyme is regulated pretranslational, translational and posttranslational |
| 1.13.11.33 | arachidonate + O2 |
induction of experimental anemia leads to a systemic up-regulation of 12/15-lipoxygenases expression |
| 1.13.11.33 | arachidonate + O2 |
15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells, it could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression |
| 1.13.11.33 | arachidonate + O2 |
catalyzes enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins |
| 1.13.11.33 | arachidonate + O2 |
the enzyme is implicated in inflammatory disorders, 15-lipoxygenase is induced in atherosclerosis and can oxidize low-density lipoprotein to its atherogenic form |
| 1.13.11.33 | arachidonate + O2 |
first step in biotransformation of arachidonic acid to the 15-series of leukotrienes, reaction is involved in inactivation of slow-reacting substrances of anaphylaxis |
| 1.13.11.33 | arachidonate + O2 |
alternative splicing of 15S-lipoxygenase provides a further level of regulation of fatty acid metabolism |
| 1.13.11.33 | arachidonate + O2 |
12/15LO protein levels and activity are increased in pathologically affected regions of Alzheimers disease brains, enzyme inhibition causes a decrease in amyloid-beta protein, 12/15LO influences amyloid-beta protein precursor protein metabolism, overview |
