EC Number |
Natural Substrates |
---|
1.1.99.2 | (S)-2-hydroxyglutarate + acceptor |
- |
1.1.99.2 | (S)-2-hydroxyglutarate + acceptor |
enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria |
1.1.99.2 | (S)-2-hydroxyglutarate + FAD |
enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria |
1.1.99.2 | (S)-2-hydroxyglutarate + NAD+ |
- |
1.1.99.2 | L-2-hydroxyglutarate + FAD |
- |
1.1.99.2 | L-2-hydroxyglutarate + NAD+ |
- |
1.1.99.2 | more |
high levels of the enzyme is produced at the late stage of cultivation in the presence of citrate and with limited aeration |
1.1.99.2 | more |
mutations (K81E, E176D, DELTA-exon9) found in patients with L-2-hydroxyglutaric aciduria supress L-2-hydroxyglutarate dehydrogenase activity. L-2-hydroxyglutartic aciduria is due to a deficiency in L-2-hydroxyglutarate dehydrogenase |