EC Number   |
Natural Substrates |
|---|
   1.1.1.315 | 11-cis-retinol + NAD+ |
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism. Substrate specificity and expression locus of Rdh5 suggest that it could serve as both an 11-cis-retinol dehydrogenase in the RPE and a 9-cis-retinol dehydrogenase and/or an androgen dehydrogenase outside of the retinal pigment epithelium |
| 1.1.1.315 | 11-cis-retinol + NAD+ |
RDH10 can utilize both NAD+ and NADP+ as cofactors for 11-cis-retinol dehydrogenase activity. NAD+ cofactor confers more robust activity. RDH10 may function in the RPE retinoid visual cycle as an 11-cis-retinol dehydrogenase, and thereby partially compensate for the loss of RDH5 function in human patients with fundus albipunctatus |
| 1.1.1.315 | 11-cis-retinol + NADP+ |
RDH10 can utilize both NAD+ and NADP+ as cofactors for 11-cis-retinol dehydrogenase activity. NAD+ cofactor confers more robust activity. RDH10 may function in the RPE retinoid visual cycle as an 11-cis-retinol dehydrogenase, and thereby partially compensate for the loss of RDH5 function in human patients with fundus albipunctatus |
| 1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ |
- |
| 1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+ |
- |
| 1.1.1.315 | 11-cis-retinol-[retinal-binding-protein] + NAD+ |
- |
| 1.1.1.315 | 9-cis-retinol + NAD+ |
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism |
| 1.1.1.315 | 9-cis-retinol + NAD+ |
the multifunctional cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase may catalyze the first step in an enzymatic pathway from 9-cis-retinol to generate the retinoid X receptor ligand 9-cis-retinoic acid and/or may regenerate dihydrotestosterone from its catabolite 5alpha-androstan-3alpha,17beta-diol |
| 1.1.1.315 | more |
dual physiological role of isoform RDH10: in the biosynthesis of 11-cis-retinaldehyde for vision and in the biosynthesis of all-trans-retinoic acid for differentiation and development |
| 1.1.1.315 | more |
cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR |
