EC Number |
Natural Substrates |
---|
1.1.1.271 | GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+ |
- |
1.1.1.271 | GDP-4-dehydro-6-deoxy-D-mannose + NADPH |
the enzyme is crucial in the biosynthesis of GDP-L-fucose together with GDP-D-mannose-4,6-dehydratase, overview |
1.1.1.271 | GDP-4-dehydro-6-deoxy-D-mannose + NADPH |
the enzyme is required for the formation of activated L-fucose |
1.1.1.271 | GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+ |
- |
1.1.1.271 | GDP-4-keto-6-deoxy-D-mannose + NADPH |
catalyzes the last two steps in the de novo synthesis of L-fucose |
1.1.1.271 | more |
fucosylation is regulated by complicated mechanisms that involve several factors: fucosyltransferases, GDP-fucose transporter, and GDP-fucose-synthetic enzymes, such as GDP-mannose 4,6-dehydratase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, and GDP-fucose pyrophosphorylase, fucose metabolism, overview |