EC Number |
Natural Substrates |
---|
1.1.1.247 | codeine + NADP+ |
- |
1.1.1.247 | Codeinone + NADPH |
neopinone, which is formed most likely by demethylation of the vinylether of thebaine exists in the plant cell in a thermodynamic equilibrium with codeinone. The presence of the codeinone reductase/NADPH system shifts this equilibrium quantitatively in the direction of codeine, which either accumulates in the latex of the poppy plant or is further demethylated at the 3-OCH3 group yielding morphine |
1.1.1.247 | Codeinone + NADPH |
biosynthesis of codeine |
1.1.1.247 | Codeinone + NADPH |
important regulating function in morphine biosynthesis |
1.1.1.247 | Codeinone + NADPH |
penultimate step in morphine biosynthesis |
1.1.1.247 | codeinone + NADPH + H+ |
- |
1.1.1.247 | more |
the enzyme is involved in the biosynthesis of morphine and the related antimicrobial alkaloid sanguinarine |
1.1.1.247 | more |
the enzyme is involved in biosynthesis of morphinan alkaloids, overview |
1.1.1.247 | more |
the enzyme is involved in biosynthesis of morphinan alkaloids, transcriptional regulation, overview |
1.1.1.247 | more |
the enzyme also catalyzes the NADPH-dependent reduction of morphinone to morphine, reaction of EC 1.1.1.218. but codeine can also be directly converted into morphine, overview |