3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O
alpha-aminoadipic acid + L-valine + L-lysine + ?
enzyme is a nonribosomal peptide synthetase (NRPS) able to form ribosome-independent peptide bonds
ATP + (R)-4-phosphopantoate + beta-alanine
the enzyme is involved in coenzyme A biosynthesis in the archaea
ACVSs are multifunctional enzymes that activate amino acids as aminoacyladenylates, forming a mixed anhydride with the a-phosphate group of ATP and releasing pyrophosphate
pure Streptomyces lactamdurans ACVS is able to activate alpha-aminoadipic acid or its lactam 6-oxopiperideine-2-carboxylic acid, a compound that is easily converted to alpha-aminoadipic acid, but is unable to use piperideine-6-carboxylate or pipecolic acid as substrates, enzyme is also able to use L-cystathionine with the same efficiency as L-cysteine