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Results 1 - 10 of 16 > >>
EC Number
Natural Substrates
Commentary (Nat. Sub.)
aggrecan + H2O
cleavage site is Asn341-Phe342
ameloblastin + H2O
N-terminal ameloblastin cleavage products of 13, 15, and 17 kDa accumulate in the sheath space throughout the enamel layer
ameloblastin + H2O
MMP-20 processes ameloblastin during the secretory stage of amelogenesis, cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage
amelogenin + H2O
amelogenin + H2O
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis
amelogenin + H2O
amelogenin constitutes more than 90% of enamel extracellular matrix proteins in secretory-stage enamel
amelogenin + H2O
MMP-20 is involved in amelogenin processing and degradation
amelogenin + H2O
most of the secreted substrate is cleaved after Ser148 to generate the 20000 Da amelogenin (Met1-Ser148), which in turn is cleaved after Trp45 to yield the tyrosine-rich amelogenin polypeptide (Met1-Trp45) and the 13000 Da amelogenin (Leu46-Ser148)
amylogenin + H2O
involved in tooth formation
cartilage oligomeric matrix protein + H2O
100 kDa protein substrate
Results 1 - 10 of 16 > >>