EC Number   |
Natural Substrates |
|---|
   3.4.23.48 | C3 protein of complement system + H2O |
- |
| 3.4.23.48 | human alpha2-antiplasmin + H2O |
- |
| 3.4.23.48 | plasminogen + H2O |
- |
| 3.4.23.48 | Yersinia outer proteins + H2O |
- |
| 3.4.23.48 | plasminogen + H2O |
activates plasminogen by cleaving the Arg560-Val561 bond |
| 3.4.23.48 | plasminogen + H2O |
activation |
| 3.4.23.48 | single-chain urokinase + H2O |
activation |
| 3.4.23.48 | alpha2-antiplasmin + H2O |
alpha2AP is the main inhibitor of free plasmin in the circulation. Pla cleaves and inactivates alpha2AP by a single, rapid cut. It appears likely that the R376-M377 bait peptide bond is targeted by Pla |
| 3.4.23.48 | plasminogen + H2O |
capacity to convert plasminogen into plasmin by the action of the outer-membrane Lpa protein determined |
| 3.4.23.48 | plasminogen activator inhibitor-1 + H2O |
inactivation. PAI-1 is the primary physiological inhibitor of uPA and t-PA and a major inhibitor of fibrinolysis. Pla rapidly inactivates PAI-1 by a single cleavage of the bait peptide at R346-M347. In circulation, most PAI-1 is bound to vitronectin, which is also degraded by Pla |
