EC Number   |
Natural Substrates |
|---|
   3.4.21.B30 | UmuD + H2O |
auto-cleavage of UmuD to UmuD' |
| 3.4.21.B30 | more |
binds to a cleft located between two RecA monomers in the crystal structure |
| 3.4.21.B30 | more |
enzyme interacts with RecA |
| 3.4.21.B30 | more |
enzyme UmuD does not bind DNA. the enzyme UmuD interacts with several components of DNA polymerase III, including the polymerase subunit alpha, the beta clamp and the proofreading subunit epsilon, homology modeling and protein-protein docking analysis, overview. It interacts with the alpha subunit of DNA polymerase III at two distinct binding sites, one of which is adjacent to the single-stranded DNA-binding site. Enzyme UmuD specifically inhibits binding of DNA polymerase III alpha to ssDNA, UmuD residues D91 and G92 are involved in this interaction, molecular modeling, overview |
| 3.4.21.B30 | more |
interacts with RecA protein |
| 3.4.21.B30 | more |
interacts with RecA-DNA filament and participates in mutagenesis |
| 3.4.21.B30 | more |
role in mutagenesis |
| 3.4.21.B30 | more |
role in SOS mutagenesis |
| 3.4.21.B30 | more |
role in UV mutagenesis |
| 3.4.21.B30 | UmuD2 + H2O |
slow auto-cleavage of UmuD2 to UmuD'2 |
