EC Number |
Natural Substrates |
---|
2.1.1.137 | more |
As3MT methylates inorganic arsenic and its metabolites |
2.1.1.137 | more |
enzyme evolutionary analysis |
2.1.1.137 | more |
genetic susceptibility to arsenic toxicity in Asian is different from Africans and Caucasians, overview |
2.1.1.137 | more |
the enzyme is responsible for the removal of arsenic as the volatile arsines from the bacteria producing trimethylarsine via successive methylation |
2.1.1.137 | more |
besides methylarsonate and dimethylarsinate, the enzyme also produces trimethylarsenite and dimethylarsine gases |
2.1.1.137 | S-adenosyl-L-methionine + arsenite |
- |
2.1.1.137 | S-adenosyl-L-methionine + arsenite |
AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans |
2.1.1.137 | S-adenosyl-L-methionine + arsenite |
hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells |
2.1.1.137 | S-adenosyl-L-methionine + arsenite |
methylation of environmental arsenic by conversion to soluble and gaseous methylated species is a detoxifying process that may contribute to global cycling of arsenic |
2.1.1.137 | S-adenosyl-L-methionine + arsenite |
As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview |