EC Number |
Natural Substrates |
---|
1.14.99.1 | arachidonate + 2 O2 |
- |
1.14.99.1 | arachidonate + AH2 + 2 O2 |
- |
1.14.99.1 | arachidonate + AH2 + O2 |
- |
1.14.99.1 | arachidonate + reduced acceptor + O2 |
- |
1.14.99.1 | prostaglandin G2 + AH2 |
- |
1.14.99.1 | more |
activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha |
1.14.99.1 | more |
dopamine precursor L-dihydroxyphenylalanine, i.e. L-DOPA, and metabolites dihydroxyphenylacetic acid, homovanillic acid, and 3-methoxytyramine may serve as substrates for prostaglandin H synthase-catalyzed bioactivation to free radical intermediates |
1.14.99.1 | more |
enzyme has a central position in prostanoic metabolism: first step in formation of prostaglandins and thromboxanes, the conversion of arachidonic acid to prostaglandin endoperoxides G and H |
1.14.99.1 | more |
first step in prostaglandin synthesis |
1.14.99.1 | more |
PGHS-2 also shows cyclooxygenase activity |