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EC Number
Natural Substrates
Commentary (Nat. Sub.)
arachidonate + 2 O2
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arachidonate + AH2 + 2 O2
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arachidonate + AH2 + O2
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arachidonate + reduced acceptor + O2
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first step in prostaglandin synthesis
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enzyme has a central position in prostanoic metabolism: first step in formation of prostaglandins and thromboxanes, the conversion of arachidonic acid to prostaglandin endoperoxides G and H
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the expression of PGHS-2 may be involved in inhibiting progesterone production
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prostaglandin synthesis within the fetal central nervous system is critical for the the modulation of hypotension-induced fetal ACTH secretion involving PGHS-2, overview
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dopamine precursor L-dihydroxyphenylalanine, i.e. L-DOPA, and metabolites dihydroxyphenylacetic acid, homovanillic acid, and 3-methoxytyramine may serve as substrates for prostaglandin H synthase-catalyzed bioactivation to free radical intermediates
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PGHS-2 also shows cyclooxygenase activity
Results 1 - 10 of 12 > >>