EC Number   |
Natural Substrates |
|---|
    1.13.11.27 | 4-hydroxyphenylpyruvate + O2 |
- |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 |
enzyme is involved in production of homogentisate, the aromatic precursor of all phenylquinones |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 |
enzyme participates in catabolism of tyrosine |
| 1.13.11.27 | more |
HpdR positively regulates hpdA expression through direct binding to the HpdA promoter within a region containing two conserved direct repeat sequences. HpdR-dependent hpdA transcription occurs in the presence of 4-hydroxyphenylpyruvate, tyrosine, and phenylalanine, as well as during starvation |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 |
hppD is transcriptionally activated by HpdA and repressed by HpdR |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 |
key enzyme involved in tyrosine catabolism, congenital 4-hydroxyphenylpyruvate dioxygenase deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 |
second step of oxidative tyrosine catabolism |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 |
the conversion of 4-hydroxyphenyl-pyruvate to homogentisate involves oxidative decarboxylation, side-chain migration and aromatic hydroxylation in a single catalytic cycle. The 4-HPPD reaction is unusual in that the 2-oxoacid and prime substrate moieties are contained within the same molecule |
