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Results 1 - 8 of 8
EC Number
Natural Substrates
Commentary (Nat. Sub.)
4-hydroxyphenylpyruvate + O2
-
4-hydroxyphenylpyruvate + O2
enzyme participates in catabolism of tyrosine
4-hydroxyphenylpyruvate + O2
key enzyme involved in tyrosine catabolism, congenital 4-hydroxyphenylpyruvate dioxygenase deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia
4-hydroxyphenylpyruvate + O2
enzyme is involved in production of homogentisate, the aromatic precursor of all phenylquinones
4-hydroxyphenylpyruvate + O2
hppD is transcriptionally activated by HpdA and repressed by HpdR
4-hydroxyphenylpyruvate + O2
the conversion of 4-hydroxyphenyl-pyruvate to homogentisate involves oxidative decarboxylation, side-chain migration and aromatic hydroxylation in a single catalytic cycle. The 4-HPPD reaction is unusual in that the 2-oxoacid and prime substrate moieties are contained within the same molecule
4-hydroxyphenylpyruvate + O2
second step of oxidative tyrosine catabolism
more
HpdR positively regulates hpdA expression through direct binding to the HpdA promoter within a region containing two conserved direct repeat sequences. HpdR-dependent hpdA transcription occurs in the presence of 4-hydroxyphenylpyruvate, tyrosine, and phenylalanine, as well as during starvation
Results 1 - 8 of 8