EC Number   |
Natural Substrates |
|---|
   3.4.22.53 | more |
m-calpain is vital for development of the preimplantation murine embryo |
| 3.4.22.53 | more |
ERp75 plays important role in the refolding of mitochondrial m-calpain large subunit, cytosolic m-calpain does not associate with ERp57 |
| 3.4.22.53 | myocillin + H2O |
calpain II is responsible for the intracellular processing of myocilin in the lumen of the endoplasmic reticulum. It is proposed that this cleavage might regulate extracellular interactions of myocilin, contributing to the control of intraocular pressure |
| 3.4.22.53 | NCX1 + H2O |
- |
| 3.4.22.53 | neurofilament + H2O |
- |
| 3.4.22.53 | nucleolin + H2O |
- |
| 3.4.22.53 | p35 + H2O |
calpain-specific substrate |
| 3.4.22.53 | selenoprotein K + H2O |
cleavage occurs only in unactivated macrophages, m-calpain cleavage at Arg81-Gly82 generates the two selenoprotein K isoforms |
| 3.4.22.53 | striatal-enriched protein tyrosine phosphatase + H2O |
calpain-2 activation cleaves striatal-enriched protein tyrosine phosphatase and activates STEP-mediated pro-death pathway in retinal ganglion cells after intraocular pressure elevation |
| 3.4.22.53 | synaptotagmin-1 + H2O |
- |
