EC Number |
Natural Substrates |
---|
3.4.22.27 | CX3CL1 + H2O |
cathepsin S is able to cleave membrane-anchored CX3CL1, releasing a 55-kDa fragment to the medium |
3.4.22.27 | more |
cathepsin S is an elastolytic enzyme |
3.4.22.27 | more |
cathepsin S is considered crucial for normal presentation of major histocompatibility complex class II-restricted antigens by antigen presenting cells to CD4+ T cells. It is a key enzyme for the degradation of the class II-associated invariant chain, a process that is required for effective antigen loading of class II molecules |
3.4.22.27 | more |
cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules |
3.4.22.27 | more |
cathepsin S is possibly involved in thyroid hormone biosynthesis |
3.4.22.27 | more |
cathepsin S is putatively involved in the pathogenesis of COPD |
3.4.22.27 | more |
cathepsin S is responsible for murine autoimmune myasthenia gravis pathogenesis, overview |
3.4.22.27 | more |
cathepsin S, a cysteine protease, plays an important role in generating peptides for the vacuolar, TAP-independent MHC class I cross-presentation in vivo |
3.4.22.27 | more |
cathepsin S-dependent activation of PAR-2 activation |
3.4.22.27 | more |
cathepsins are primarily involved in general protein turnover, CATS belongs to the cathepsins with a distinct substrate specificity |