EC Number   |
Natural Substrates |
|---|
   3.4.22.27 | Ii protein + H2O |
inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments |
| 3.4.22.27 | Ii-p10 + H2O |
i.e. MHC classe-associated invariant chain, cathepsin S is the only human cysteine protease able to efficiently degrade the Ii-p10 fragment in epithelial cells |
| 3.4.22.27 | insulin + H2O |
degradation |
| 3.4.22.27 | invariant chain + H2O |
invariant chain li is degraded by CatS to the class II-associated invariant chain peptide which dissociates from the MHC-II molecule by forming a complex with the human leucocyte antigen-DM |
| 3.4.22.27 | laminin alpha5-chain + H2O |
the laminin-alpha5-chain is cleaved by CatS specifically at the Ser-Val bond |
| 3.4.22.27 | laminin-5 + H2O |
degradation |
| 3.4.22.27 | MHC class II-associated invariant chain Ii + H2O |
degradation, cathepsin S and MHC class II-associated invariant chain Ii are responsible for in vivo control of endosomal size and multivesicular morphology |
| 3.4.22.27 | more |
- |
| 3.4.22.27 | more |
cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules |
| 3.4.22.27 | more |
primary role of the enzyme in heterophagocytosis of proteins from the ultrafiltrate |
