EC Number   |
Natural Substrates |
|---|
   3.4.22.10 | more |
SpeB has no immunoglobulin-degrading activity in human plasma or blood |
| 3.4.22.10 | mouse CXCL-1 + H2O |
the cleavage site is between lysine residues K65 and K66 |
| 3.4.22.10 | mouse CXCL-2 + H2O |
the cleavage site is between lysine residues K65 and K66 |
| 3.4.22.10 | plasminogen + H2O |
- |
| 3.4.22.10 | pro-interleukin-1beta + H2O |
cleavage site is YVH-D |
| 3.4.22.10 | properdin + H2O |
- |
| 3.4.22.10 | properdin + H2O |
cleavage of properdin leads to inhibition of complement-mediated opsonophagocytosis and bacterial killing by neutrophils, alternative complement pathway overview |
| 3.4.22.10 | protein F1 + H2O |
- |
| 3.4.22.10 | protein F1 + H2O |
SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1, e.g. in human pharyngeal epithelial cells Detroit 562, while proteins H and M1 are protected by plasma proteins, overview |
| 3.4.22.10 | protein H + H2O |
- |
