EC Number   |
Natural Substrates |
|---|
   2.7.11.25 | more |
phosphorylates and activates MAP kinase kinase, involved in cellular stress response and JNK and p38 pathway activation, MLK1, 2 and 3 knockout mice show no obvious abnormalities, MLK 7 is activated in response to stressors like anisomycin and UV radiation and activates pro-apoptotic pathways through p38 and JNK |
| 2.7.11.25 | more |
phosphorylates and activates MAP kinase kinase, regulates apoptosis in response to stress stimuli, knockout mice do not exhibit developmental defects, activates p38 and JNK pathways |
| 2.7.11.25 | more |
phosphorylates and activates MAP kinase kinase, regulates p38,ERK1/2 and JNK, knockout embryos dying in utero due to abnormalities in vessel development and heart development, key regulator of cardiovascular and nervous system formation |
| 2.7.11.25 | more |
phosphorylates and activates MAP kinase kinase, regulation of apoptosis, induction of the MEK/ERK pathway, promotes cell survival in the heart through modulation of MEKK5 activity, important physiological role in cell growth and development, related to oncogenesis |
| 2.7.11.25 | more |
phosphorylates and activates MAP kinase kinase, selctive for the activation of JNK and ERK5, knockout mutants are viable and fertile without apparent malformations, involved in T-cell receptor modulation and cytokine production in response to IgE |
| 2.7.11.25 | more |
MKK1 and MKK2 interact with MEKK1 and MPK4 in vivo, and activation of MPK4 by flg22 requires MEKK1 as well as MKK1 and MKK2, suggesting that MEKK1, MKK1/MKK2, and MPK4 form a MAPK cascade to negatively regulate plant immune responses |
| 2.7.11.25 | more |
possible mechanismof ILA1 action, interaction analysis with possible substrate proteins, overview |
