EC Number   |
Natural Substrates |
|---|
   1.14.19.3 | more |
fatty acid DELTA6-desaturation is the first commited step in C20 polyunsaturated fatty acid biosynthesis |
| 1.14.19.3 | linoleic acid + AH2 + O2 |
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid |
| 1.14.19.3 | linoleic acid + AH2 + O2 |
key enzyme localized in the endoplasmic reticulum |
| 1.14.19.3 | palmitic acid + AH2 + O2 |
key enzyme required for numerous vital functions involving distinct polyunsaturated fatty acids and polyunsaturated fatty acid-derived bioactive lipids. It seems that the biological importance of DELTA6-desaturase activity should also be considered for its newly identified role in the control of the biosynthesis of a monoenoic fatty acid (C16:1 n-10), particularly in tissues with low DELTA9-desaturase activity |
| 1.14.19.3 | more |
PiDes6 desaturates both omegax6 and omega3 substrates, substrate specificity in comparison to other fatty acid desaturases, overview |
| 1.14.19.3 | more |
polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels |
| 1.14.19.3 | alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ |
preferred substrate |
| 1.14.19.3 | linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ |
preferred substrate |
| 1.14.19.3 | palmitate + AH2 + O2 |
the enzyme is a component of the lipid metabolic pathway that converts the essential fatty acids linoleate and alpha-linolenate into long-chain polyunsaturated fatty acids. The DELTA-6 desaturase/FADS2 expressed in human sebocytes catalyzes the conversion of palmitate into sapienate |
| 1.14.19.3 | more |
the enzyme is essential for the formation of long-chain metabolites from dietary linoleic acid and alpha-linolenic acid, but shows a slow activity in humans. A defect in the activity of DELTA6 and DELTA5 desaturases decreases the formation of gamma-linolenic acid, dihomo-gamma-linoleic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid from dietary linoleic acid, and alpha-linolenic acid. This, in turn, leads to inadequate formation of prostaglandins E1 and I3, prostacyclin, lipoxins resolvins, neuroprotectin D1, NO, and nitrolipids that have anti-inflammatory and platelet anti-aggregatory actions, inhibit leukocyte activation, augment wound healing, and resolve inflammation and thus, leads to the initiation and progression of atheroslcerosis, metabolism of essential fatty acids, overview, enzyme activity is decreased in diabetes mellitus, hypertension, hyperlipidemia, and metabolic syndrome X |
