EC Number   |
Natural Substrates |
|---|
    1.13.11.34 | more |
the enzyme is involved in lipoxin synthesis from 5,15-dihydroxyperoxyeicosatetraenoic acid via 5,6-epoxide |
| 1.13.11.34 | more |
enzyme of leukotriene biosynthetic pathway |
| 1.13.11.34 | more |
key enzyme in leukotriene metabolism, in human mast cells glucocorticoids effectively and selectively upregulate the expression |
| 1.13.11.34 | more |
key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions |
| 1.13.11.34 | more |
key enzyme in the biosynthesis of proinflammatory leukotrienes |
| 1.13.11.34 | more |
5-lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells, overview |
| 1.13.11.34 | more |
5-LO inhibition in obese mice downregulates genes involved in hepatic fatty acid uptake, i.e. L-FABP and FAT/CD36, and normalizes PPARalpha and acyl-CoA oxidase expression, whereas the expression of lipogenic genes, i.e. FASN and SREBP-1c, remains unaltered. The 5-LO inhibition restores hepatic microsomal triglyceride transfer protein, MTP, activity in parallel with a stimulation of hepatic VLDL-TG and ApoB secretion in obese mice, overview |
| 1.13.11.34 | more |
5-LOX is the key enzyme in the biosynthesis of leukotrienes through catalyzing the initial two steps in conversion of arachidonic acid to leukotrienes |
| 1.13.11.34 | more |
ALOX5-derived lipid mediators leukotrienes and lipoxins have regulatory functions in inflammation by modulating activities of immune cells and cytokine production, host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase |
| 1.13.11.34 | more |
inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response, overview |
