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<< < Results 51 - 59 of 59
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the enzyme can enhance the invasion ability of group A streptococci in human respiratory epithelial cells
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the enzyme can induce apoptosis in A549 cells, the induction of apoptosis in cells requires the protease activity and the propper enzyme size of 28 kDa, cell binding activity of processed and unprocessed wild-type and mutant enzymes, the induction can be prevented by inhibition of caspase-8, induction cascade, overview
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the enzyme inactivates the metabolic activity of polymorphonuclear cells, the enzyme causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A Streptococcus, it is essential for bacterial survival in blood, mechanism, overview
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the enzyme is a virulence factor of Streptococcus pyogenes inducing the release of histamine in mast cells, basophils, and mononuclear cells, and increasing capillary permeability and histamine release in skin of guinea pigs, the recombinant enzyme shows mitogenic activity with human T-cells
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the enzyme is an important virulence factor
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the enzyme is not critical for the development of tissue necrosis, bacteremia and lethal infection in a murine model of human necrotizing fascilitis
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the enzyme is secreted under conditions of starvation and may be involved in nutrient acquisition
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more the expression of the enzyme contributes to soft tissue pathology, including necrosis, and is required for efficient systemic dissemination of the organism from the initial site of skin inoculation
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.10more thus, although IgG might by a substrate for SpeB under certain environmental conditions, it seems unlikely that SpeB is part of the first line of defense against specific antibodies. Even though SpeB might not be directly involved in the attenuation of the adaptive immune response, its proteolytic activity towards streptococcal surface proteins, including IgG-binding proteins and the streptococcal C5a peptidase, could certainly be important for the modulation of the complement system
<< < Results 51 - 59 of 59