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EC Number
Natural Substrates
Commentary (Nat. Sub.)
3.4.22.10
human CXCL-1 + H2O
the cleavage site is between lysine residues K60 and K61
3.4.22.10
human CXCL-2 + H2O
the cleavage site is between lysine residues K60 and K61
3.4.22.10
human CXCL-6 + H2O
-
3.4.22.10
human CXCL-8 + H2O
-
3.4.22.10
human CXCL10 + H2O
-
3.4.22.10
Human fibrinogen + H2O
release and processing, the enzyme abolishes the binding of Streptococcus pyogenes to full-length or 30 kDa fragment of human fibrinogen Fn, kinetics overview
3.4.22.10
IgG + H2O
the ability to cleave off the Fc part of antigen-bound IgG contributes to the escape of group A streptococci from opsonophygocytosis while not interfering with the formation of a host-like coat by unspecific IgG binding
3.4.22.10
immunoglobulin A + H2O
cleavage sites are the heavy chains
3.4.22.10
immunoglobulin D + H2O
cleavage sites are the heavy chains
3.4.22.10
immunoglobulin E + H2O
cleavage sites are the heavy chains
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