EC Number   |
Metals/Ions |
Reference |
|---|
   4.2.2.1 | Ca2+ |
- |
655681, 655996, 656150 |
| 4.2.2.1 | Ca2+ |
50 mM, 111% of initial activity |
746795 |
| 4.2.2.1 | Ca2+ |
activates |
657325 |
| 4.2.2.1 | Ca2+ |
activates, bridges between enzyme and substrate |
656480 |
| 4.2.2.1 | Ca2+ |
binding modulates enzyme structure |
655324 |
| 4.2.2.1 | Ca2+ |
interacts with the collagenous Gly-X-Y motif of the enzyme, activates up to 20 mM, but inhibits at higher concentrations |
729322 |
| 4.2.2.1 | Ca2+ |
optimum concentrations are 5, 50, and 100 mM calcium ions for degradation of hyaluronan, chondroitin sulfate C, and chondroitin sulfate A, respectively |
748522 |
| 4.2.2.1 | Ca2+ |
required |
730258 |
| 4.2.2.1 | Mg2+ |
weak activation |
714651 |
| 4.2.2.1 | Mn2+ |
82% of the activity with Ca2+ |
748522 |
