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Results 1 - 5 of 5
EC Number Metals/Ions Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.83Ca2+ activation at 5-10 mM CaCl2 650148
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.83Ca2+ calcium ions impede the reverse transition to the closed form. The reduction in the thermal stability of PSP in the presence of Ca2+ can be attributed to the destruction of the salt bridges SB2 and SB3 that takes place as Ca2+ binds to the E494 and D460 residues parxadtaking in bridge formation. Calcixadum ions are a destabilizing factor for all PSP mutant variants, overview 752409
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.83Ca2+ in presence of Ca2+, efficiency of hydrolysis of substrates with positively charged P2 residues decreases by an order of magnitude due to the worsening in the substrate binding. In the presence of 50 mM Ca2+, no substrate inhibition is observed in the case of acetyl-L-Leu-L-Lys-L-Arg-4-nitroanilide, and the effect was less pronounced for other substrates 717235
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.83Ca2+ required 752738
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.83Ca2+ stimulates amidase and proteolytic activities, maximal activation of 25% at concentrations above 25 mM 29785
Results 1 - 5 of 5