EC Number   |
Metals/Ions |
Reference |
|---|
   3.4.21.69 | Ca2+ |
- |
650160, 652284, 683258, 683293, 683295, 683681, 684085 |
| 3.4.21.69 | Ca2+ |
a group of four or five divalent cation binding sites in the Gla-domain show a high specificity for Ca2+. Ca2+ interactions are essential for the anticoagulant functions of APC and are influenced by mutations in different regions of the Gla-domain |
718418 |
| 3.4.21.69 | Ca2+ |
binds to phospholipid both in presence and absence of Ca2+ |
29603 |
| 3.4.21.69 | Ca2+ |
contains gamma-carboxyglutamic acid residues required for Ca2+-dependent membrane binding |
29599 |
| 3.4.21.69 | Ca2+ |
decreases the binding affinity of APC and Tie2 at 1 mM and 1-12 h |
753217 |
| 3.4.21.69 | Ca2+ |
required |
683627, 683629, 683652, 683653, 683655 |
| 3.4.21.69 | Ca2+ |
required for optimal activity |
651972 |
| 3.4.21.69 | Ca2+ |
required, calcium enhances the amidolytic activity of APC by 2fold, the Ca2+ and Na+ metal ion-binding sites are linked energetically |
683670 |
| 3.4.21.69 | Ca2+ |
significantly increases recombinant activated protein C binding to the neutrophil surface |
696948 |
| 3.4.21.69 | Ca2+ |
the activated enzyme induces cytsolic Ca2+ signals, mechanism |
684102 |
